Overall Van Otterloo Lab Objective Can you imagine trying to prevent, diagnose, and/or fix the breakdown of a complicated machine (e.g., car engine) without fully understanding how each part was assembled, placed, & functions? Likewise, our DNA encodes the information (e.g., through genes and their products) needed to assemble and properly place (e.g., non-coding regulatory elements) the building blocks needed for the intricate process of fetal development. Our overall goal is to use animal models (which share an incredible similarity in their DNA code to humans) in deciphering how genes—and their encoded proteins—regulate human embryogenesis (focusing on cranio- and orofacial structures) & how these mechanisms are dysregulated in human developmental disorders. This information will allow the 'mechanic' to better predict, diagnose, and ultimately prevent or fix these disorders.